Only free Tst is converted to dihydrotestosterone (DHT), by the enzyme 5-alpha reductase type 2 isoenzyme present in the outer root sheath of the hair follicles.[4,5] This isoenzyme predominates in the testes, prostate, and the hair follicles of beard and genital hair DHT causes terminalisation of the vellus hair and prolongs the anagen phase resulting in longer thicker hairs. IH with normal androgen levels is postulated to result from exaggerated peripheral 5-alpha reductase activity, androgen receptor polymorphisms, or altered androgen metabolism."
Evo naučne potvrde da Dihidrotestosteron, (a ne Testosteron) izaziva Hirzutizam i PCOS.
Još jasnije se vidi kod primene terapija:
"Spironolactone (SPA) is an androgen blocker and competes with DHT for binding to the androgen receptor. SPA also has variable progestational activity and decreases production of ovarian androgens. SPA has an inhibitory effect on 5 alpha-reductase activity (5-RA) and competes with androgens for binding to SHBG"
Terapija se bazira na tome da SPA (lek) dopre do androgenih receptora folikula dlake - pre Dihidrotestosterona.
Ako pak DHT dođe u kontakt sa folikulom, imaćete pravu mušku dlaku, debelu, crnu i dugu, umesto nežne tanke i jedva primetne ženske dlačice.
Dalje sledi:
"Finasteride, a 5-alpha reductase inhibtor has been found to be effective in the treatment of IH.[22] Finasteride primarily inhibits type 2 5-RA activity. A 5-RA inhibitor still in clinical testing is dutasteride (GI198745, GlaxoWellcome Co., Research Triangle Park, NC), a “dual” type 1 and type 2 5-RA inhibitor. It is predicted that this drug will be more potent than finasteride. This compound effectively inhibits DHT production by 99% approximately 24 h after oral administration."
Korišćenje lekova za BHP u borbi protiv Hirzutizma potvrđuje teoriju da je DHT osnovni uzročnik ovih androgeno uslovljenim ženskim poremećajima hormonske ravnoteže. Zna se da se gore navedeni lekovi koriste za snižavanje koncentracije DHT a kod problema sa prostatom. Sintetički alfa 5 inhibitori.
Prema tome, nije Testosteron glavni krivac za androgeni suficit i poremećaje koje generiše. Dihidrotestosteron je po meni jako problematičniji (alopecija, hirzutizam, akne, PCOS).
Uzimanjem prirodnih alfa 5 inhibitora, organizmu sigurno nećete naneti nikakvu štetu, a o efektima možemo da diskutujemo.